Back to Best of 2018 - All about asparaginase
Best of 2018 - All about asparaginase

Best of 2018 - All about asparaginase


Joshua Elder, PharmD BCOP BCPS

Product Details

Asparaginase therapy is an integral component of achieving desirable outcomes in leukemia patients. Although asparaginase therapies have been a mainstay in pediatric acute lymphoblastic leukemia protocols for quite some time, as our understanding of their importance grows, these therapies are increasingly being used in adolescent and young adult protocols. Asparaginase therapy has many intricacies with regard to efficacy and safety. This presentation will review both the benefits of asparaginase therapies on treatment outcomes and their adverse-effect profile. The management of these adverse effects, including the differentiation of anaphylactic reactions versus infusion-related reactions, will be discussed in detail. We will also discuss the appropriateness of interchanging asparaginase products. Finally, we will focus on the utility and functionality of asparaginase monitoring through a review of recent literature on the pharmacokinetics and pharmacodynamics of the available formulations and optimization of monitoring to increase efficacy. This topic is especially timely because of the lack of national standardization in this area of practice and the recent publication of consensus recommendations for how asparaginase monitoring should be carried out.

  • List Price: $35.00 USD
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